Chiral cyclopentadienylruthenium sulfoxide catalysts for asymmetric redox bicycloisomerization

• Barry M. Trost,
• Michael C. Ryan and
• Meera Rao

Beilstein J. Org. Chem. 2016, 12, 1136–1152, doi:10.3762/bjoc.12.110

• alcohols revealed a matched/mismatched effect that was strongly dependent on the nature of the solvent. Keywords: asymmetric catalysis; [3.1.0] bicycles; [4.1.0] bicycles; cycloisomerization; 1,6-enyne; 1,7-enyne; ruthenium catalysis; sulfoxide; Introduction Due to their prevalence in natural products [1

• for chiral sulfoxide synthesis. (a) General synthetic sequence to access enyne bicycloisomerization substrates (b) Synthesis of 2-cyclopropylprop-2-en-1-ol using a modified Suzuki coupling reaction developed by Soderquist. Deprotection of [3.1.0] bicycles and X-ray crystal structure of 76. ProPhenol